Preheat Oven: Set your oven to 350°F and prepare a 9×13 baking dish with cooking spray.
Cook Meat: In a skillet over medium heat, cook the ground beef until no longer pink, then drain any excess fat.
Prepare Sloppy Joe Mixture: To the skillet, add ketchup, water, brown sugar, Worcestershire sauce, mustard, garlic powder, onion powder, and salt. Simmer for about 5 minutes.
Combine with Biscuits: Remove the skillet from heat and transfer the meat mixture to a medium bowl. Toss the quartered biscuits with the meat mixture until well combined.
Assemble Casserole: Transfer the biscuit and meat mixture to the prepared baking dish, spreading evenly. Top with shredded cheddar cheese.
Bake: Place the dish in the oven and bake for 28-30 minutes, or until the biscuits are golden brown and the cheese is melted.
Serve: Remove from the oven and serve warm.